Choose from 50 vacation rentals located in Seneca, South Carolina. Top filters in Seneca include Internet / Wifi, Air conditioner, and Kitchen or Kitchenette. Prices range from $60 to $1,109 per night. Our most popular vacation rental types near Seneca are Apartment and Hotel.

Top vacation rentals in Seneca

Property grounds
4.8
Outstanding(152 Reviews)
Quiet cove, deep water, minutes to Clemson, pet friendly, easy path to the dock
House
 in Seneca
8 guests · 5 bedrooms · 3 baths
Garden · Pets allowed · Kitchen or Kitchenette

This attractive House in Seneca, $230 per night for your (business stay, family stay, couples stay, getaway vacation, etc.)

$$$$
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Fridge, microwave, oven, stovetop
5.0
Outstanding(95 Reviews)
7mi to Clemson Custom Family Luxury Lakehome Game room+ Basketball+ Fire Pit
House
 in Seneca
10 guests · 5 bedrooms · 6 baths
Garden · Kitchen or Kitchenette · Air conditioner

Looking for the perfect place to call home during your trip to Seneca? This House offers a comfort and style with top-notch amenities, including Air conditioner, Dishwasher and Internet / Wifi, and more.

$$$$
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Restaurant/places to eat, Dining area, On site, Breakfast
Days Inn by Wyndham Seneca-Clemson
Motel
 in Seneca
1 king bed
Pool · Pets allowed · Kitchen or Kitchenette

Enjoy the best of Seneca in our Motel, Days Inn by Wyndham Seneca-Clemson. A stunning property with amenities including Air conditioner, Internet / Wifi and Pets allowed, and more.

$$$$
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Property building
4.5
Excellent(166 Reviews)
Hampton Inn & Suites Seneca-Clemson Area
Hotel
 in Seneca
3star
1 king bed
Pool · Kitchen or Kitchenette · Air conditioner

Looking for a business stay, family stay, couples stay, getaway vacation, or traveling to Seneca, at $88 per night for your next great vacation.

$$$$
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Vacation rentals with internet & wifi in Seneca

Terrace/patio
4.9
Outstanding(102 Reviews)
Beautiful Home on Lake Keowee- Deep Water Dock- 4bd/4ba -Close to Clemson
House
 in Seneca
15 guests · 5 bedrooms · 4 baths
Garden · Pets allowed · Kitchen or Kitchenette

Enjoy the best of Seneca in our House, Beautiful Home on Lake Keowee- Deep Water Dock- 4bd/4ba -Close to Clemson. A stunning property with amenities including Air conditioner, Dishwasher and Fireplace, and more.

$$$$
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Fridge, microwave, oven, stovetop
4.8
Outstanding(54 Reviews)
Comfortably Designed Lake Keowee Waterfront, Minutes to Clemson- In Seneca
House
 in Seneca
10 guests · 5 bedrooms · 4 baths
Kitchen or Kitchenette · Air conditioner · Internet / Wifi

This attractive House in Seneca, $720 per night for your (business stay, family stay, couples stay, getaway vacation, etc.)

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Property grounds
5.0
Outstanding(52 Reviews)
Tee House on BEAUTIFUL Lake Keowee
House
 in Seneca
8 guests · 4 bedrooms · 4 baths
Kitchen or Kitchenette · Air conditioner · Internet / Wifi
Top rated

Nestled in Seneca, this House is perfect for your next vacation. Enjoy Tee House on BEAUTIFUL Lake Keowee's top-rated amenities, including Air conditioner, Dishwasher and Fireplace, and more.

$$$$
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Property building
4.5
Excellent(96 Reviews)
Fairfield Inn & Suites Seneca Clemson Univ Area
Hotel
 in Seneca
2 queen beds
Pool · Kitchen or Kitchenette · Air conditioner

Looking for the perfect place to call home during your trip to Seneca? This Hotel offers a comfort and style with top-notch amenities, including Air conditioner, Internet / Wifi and Balcony or Patio, and more.

$$$$
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Seneca

Seneca travel guide

Let us help you plan your perfect Seneca vacation. Our travel guide highlights things to do, places to see, favorite vacation rental amenities in Seneca, and more.

Frequently asked questions

What are the most popular vacation rental amenities in Seneca?

  • Internet / Wifi
  • Air conditioner
  • Kitchen or Kitchenette

What are the must-visit tourist attractions in Seneca, SC?

Seneca, SC is a beautiful city with many must-visit tourist attractions. Here are some of the top attractions:

  • Oconee Station State Historic Site
  • Keowee-Toxaway State Natural Area
  • Westminster Heritage Museum
  • Issaqueena Lake Park
Visitors can also explore the nearby Clemson University campus, take a boat tour of Lake Keowee, and visit the nearby Oconee State Park. Seneca, SC is a great destination for anyone looking to explore the outdoors and experience the local culture.

How can I get around in Seneca, SC?

You can get around Seneca, SC in the following ways:

  • By car
  • By bike
  • By foot

Seneca is a small town, so it is easy to get around by walking or biking. You can also rent a car or use public transportation to get around the town.

Where can I find affordable accommodation in Seneca, SC?

Seneca, SC offers a variety of affordable accommodation options. Here are a few to consider:

  • Holiday Inn Express Seneca: Located in the foothills of the Blue Ridge Mountains, this hotel offers comfortable rooms at an affordable rate.
  • Americas Best Value Inn Seneca: This hotel offers budget-friendly rates and is conveniently located near local attractions.
  • Seneca Motel: This motel offers basic rooms at an affordable rate.
  • Seneca Inn: This hotel is located in the heart of the city and offers comfortable rooms at a reasonable price.

What is the culture like in Seneca, SC?

Seneca, SC is a small town in Upstate South Carolina with a population of around 9,000 people. The culture of Seneca is one of small-town charm with a strong sense of community. Here are five aspects of the culture in Seneca:

  • Community involvement - Seneca residents are active in supporting their town, participating in events, and getting to know their neighbors.
  • Outdoor activities - The nearby Blue Ridge Mountains provide ample opportunities for hiking, camping, fishing, and other outdoor activities.
  • Family-friendly atmosphere - Seneca is a great place to raise a family, with plenty of activities for kids and parents alike.
  • Southern hospitality - Residents are friendly and welcoming, making it easy to make friends and feel at home.
  • Unique cuisine - Seneca is home to a variety of unique restaurants, offering everything from classic Southern cooking to more eclectic options.

Is Seneca, SC safe to travel to?

Seneca, SC is a safe place to travel to. Here are a few things to consider:

  • The city has a low crime rate.
  • The city is well-lit and has plenty of security.
  • The people in the city are friendly and welcoming.

What are the popular shopping destinations in Seneca, SC?

Seneca, SC is known for its many popular shopping destinations. Here are a few of the top spots:

  • Seneca Mall
  • Walmart Supercenter
  • Oconee Station Shopping Center

These destinations offer shoppers a wide variety of stores, restaurants, and services.

What are the best neighborhoods to visit in Seneca, SC?

The best neighborhoods to visit in Seneca, SC are:

  • Downtown Seneca
  • Gambrell Street
  • The Village at Seneca

Downtown Seneca is home to a variety of restaurants, shops, and entertainment venues. Gambrell Street is a historic district with a unique mix of old and new architecture. The Village at Seneca offers a variety of outdoor activities and a great view of the lake.

Where is Seneca, SC?

Seneca, SC is located in the northwest corner of the state, in Oconee County. It is situated on the shores of Lake Keowee and is a popular destination for outdoor activities such as fishing, camping, and boating. It is also close to the Blue Ridge Mountains, making it a great spot for hiking and exploring the area's natural beauty.

What are the most popular vacation rental amenities in Seneca, SC?

Vacation rentals in Seneca, SC offer a variety of amenities for their guests to enjoy. Here are some of the most popular amenities:

  • Fully-equipped kitchens
  • Outdoor recreation areas
  • Private pools
  • Wi-Fi access
  • Game rooms

These amenities provide travelers with all the comforts of home while allowing them to enjoy the outdoors. Whether you are looking for a quiet getaway or an active vacation, Seneca offers something for everyone. From fishing and boating to exploring the local attractions, there is plenty to do and see.

What are the top things to do in Seneca, SC?

Seneca, SC is a great place to visit for a variety of activities. Here are some of the top things to do in Seneca:

  • Go fishing at Lake Keowee
  • Explore the Issaqueena Lake Trail
  • Visit the Hagood Mill Historic Site
  • Check out the Clemson Outdoor Lab

Whether you're looking for a relaxing day outdoors or a fun adventure, Seneca has something for everyone to enjoy.

What do I need to know before visiting Seneca, SC?

Seneca is a small city in South Carolina, located in Oconee County, near the border of Georgia. Before visiting, it is important to be aware of the following:
  • The local time zone is Eastern Standard Time.
  • The closest airport is in Greenville, SC (GSP).
  • The local climate is mild, with temperatures ranging from 50-90 degrees Fahrenheit.

Seneca is a small city in South Carolina, located in Oconee County, near the border of Georgia. Before visiting, it is important to be aware of the following:

  • The local time zone is Eastern Standard Time.
  • The closest airport is in Greenville, SC (GSP).
  • The local climate is mild, with temperatures ranging from 50-90 degrees Fahrenheit.

What is the price range for rentals in Seneca?

Vacation rentals in Seneca have a price range between $60-$1,109. The average price for rentals in Seneca is $208 per night.

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